Skip to content 
Search

Latest Stories

India concludes clinical trials for world's first injectable male contraceptive

According to the study, with an ever-increasing world population, there is an urgent need to develop modern methods of male contraception for population control

India concludes clinical trials for world's first injectable male contraceptive

The Indian Council of Medical Research (ICMR) has successfully concluded clinical trials for the world's first injectable male contraceptive. The trials demonstrated its safety and high efficacy, with no significant side effects reported.

The results of the phase-III clinical trial, which involved 303 participants aged 25-40 years were published last month in the international open-access journal Andrology.


The open-labelled and non-randomised, multi-centre hospital-based phase-III clinical trials were carried out at five different centres (New Delhi, Udhampur, Ludhiana, Jaipur, and Kharagpur) and coordinated by the ICMR, New Delhi.

Permission to conduct phase-III clinical trials was granted by the Drugs Controller General India (DCGI) and approved by the institutional ethical committees of the respective centres.

As part of the study, 303 healthy, sexually active, and married men and their healthy and sexually active wives who came to the family planning clinic and department of urology or surgery for vasectomy or No Scalpel Vasectomy (NSV) were identified.

The men were injected with 60 mg of Reversible Inhibition of Sperm under Guidance (RISUG).

"The overall efficacy of RISUG with respect to achieving azoospermia was 97.3 per cent and based on pregnancy prevention was 99.02 per cent without any serious side effect," the study stated.

"In the history of contraceptive development, RISUG presents the highest effectiveness compared to all other contraceptives both male and female as they were at the threshold of induction into a mass contraception programme," it said.

According to the study, with an ever-increasing world population, there is an urgent need to develop modern methods of male contraception for population control.

Even though vasectomy is quite effective as a contraceptive measure, some major limitations of this method call for the development of improved techniques.

An ideal male contraceptive approach should have minimally invasive drug delivery system with a one-time injection, long-term effectiveness with negligible side-effects and the option of reversal.

"To achieve these goals, a novel male contraceptive approach of Reversible Inhibition of Sperm under Guidance (RISUG) has been developed, which has the potential to become for mass use as once injectable and reversible male contraceptive method.

Significant features of this method include localised injection and no detectable interaction with other body parts unlike the hormonal injectable contraceptives," the study said.

(PTI)

More For You

Southport

Floral tributes left by members of the public are seen following the fatal knife attack on three young girls in July in Southport.

Reuters

Public inquiry begins into Southport girls' murders

A PUBLIC inquiry begins on Tuesday into the murders of three young girls at a Taylor Swift-themed dance event in Southport last year.

The inquiry will examine whether the attack could have been prevented and how future incidents might be avoided.

Keep ReadingShow less
Starmer-Getty

Starmer is facing a Labour backbench revolt over plans to reform special needs support in schools without guaranteeing existing legal rights. (Photo: Getty Images)

Getty Images)

Starmer faces Labour pushback over SEND reform plans

KEIR STARMER is facing a backlash from Labour MPs over plans to reform special educational needs and disabilities (SEND) support, after ministers stopped short of guaranteeing legal rights for parents.

Education Secretary Bridget Phillipson said the government was committed to reforming the current system, which costs £12 billion a year. However, she did not confirm if legally enforceable rights, such as those provided by education, health and care plans (EHCPs), would remain.

Keep ReadingShow less
Heavy rain and thunderstorms hit London

Londoners faced a wet and stormy start to the week

iStock

Heavy rain and thunderstorms hit London before 30°C heatwave

Key points

  • Heavy rain and thunderstorms drench London at the start of the week
  • Temperatures set to rise with highs of 31°C expected by Thursday
  • Heatwave could be declared by Friday if warm conditions persist
  • Night-time temperatures to remain high, increasing discomfort
  • UV and pollen levels forecast to be very high across the south

Thunderstorms soak London before summer heat returns

Londoners faced a wet and stormy start to the week as heavy rain and overnight thunderstorms swept through the capital. Monday morning saw widespread downpours, leaving commuters reaching for umbrellas and Wimbledon ticket hopefuls queuing in ponchos.

The unsettled conditions followed a burst of thunderstorms on Sunday afternoon and continued into the early hours of Monday, prompting caution across the city. The Met Office has not issued a formal weather warning for thunderstorms, but conditions remain unstable.

Keep ReadingShow less
National Trust sets vision to heal
nature and engage more Asians

Lisa Nandy, Steve Reed, René Olivieri and Hilary McGrady at a National Trust event marking its 130th anniversary

National Trust sets vision to heal nature and engage more Asians

THE National Trust, which is seeking to broaden its appeal to British Asians, is marking its 130th anniversary with a renewed commitment to restoring nature and widening access under a 10-year strategy.

Its director-general, Hilary McGrady, also aims to inspire more people to get involved in caring for the country’s natural resources.

Keep ReadingShow less
 7/7 bombings

The King said the public should draw on the 'extraordinary courage and compassion' shown in response to the attacks. (Photo credit: X/@RoyalFamily)

Starmer and King Charles pay tribute on 20th anniversary of 7/7 bombings

PRIME MINISTER Keir Starmer and King Charles on Monday paid tribute to the unity shown in the aftermath of the 7 July bombings in London, as the country marked 20 years since the attacks.

On 7 July 2005, four Islamist extremists carried out suicide bombings at Aldgate Station, Edgware Road, King's Cross and Tavistock Square. The attacks killed 52 people and injured hundreds more.

Keep ReadingShow less