Exploring Mesenchymal Stem Cells and Their Accessibility in Parkinson’s Disease Treatment
Parkinson’s disease is a progressive neurodegenerative disorder in which the patient has various motor symptoms. In the later Parkinson’s disease stages, the motor symptoms worsen, and the patient also develops nonmotor symptoms.
Parkinson’s disease is believed to be caused due to the loss of dopaminergic neurons in the substantia nigra pars compacta, which is part of the basal ganglia. The loss of neurons leads to movement slowing, as seen in Parkinson’s disease. Patients with Parkinson’s disease have characteristic symptoms such as bradykinesia (slow movements), rigidity, resting tremors, walking instability, and falls. Some non-motor symptoms include expressionless faces, sleep disturbances, depression, and cognitive decline.
Although the mechanism of Parkinson’s disease is understood to a certain extent, the current treatments only slow down the process for a bit before becoming ineffective. But with stem cells, researchers hope to change the landscape of Parkinson’s disease treatment options and hopefully provide patients with an option that not only significantly slows down disease progression but also manages to improve them.
Understanding the Financial Aspects of MSC Therapy for Parkinson’s Disease
Mesenchymal stem cell therapy is not new, but its use for Parkinson’s disease is somewhat new. It is also more costly than the normally used treatment options, oral medicines.
MSC therapy requires a lot of steps and procedures, and to ensure the procedure's safety, a lot of money is spent on the technology. MSC is not as simple as extracting and injecting cells into the patient. Some various steps and conditions need to be taken care of.
When the cells are extracted, whether from the patient or the donor, they must be extracted carefully and in a sterile environment. Then, they must be cultured with the appropriate growth factor before being injected into the patient. If, at any point, something goes wrong, the entire procedure fails. So, higher costs also ensure higher success rates.
The cost is not just for the procedure but also for evaluations before and after the procedure. So, patients must spend money to get tested to ensure they are suitable candidates. After the procedure, they must follow up with the doctor regularly to ensure that everything is going to plan. All this adds to the cost, too.
What factors determine the cost of MSC Therapy for Parkinson’s Disease?
Like any treatment option, various factors determine the cost of stem cell therapy for Parkinson’s disease. Five significant factors influence the cost of the therapy. These factors are –
The type of cells used.
The sourcing of the cells.
The number of cells acquired.
The lab in which the cells are cultured.
The quality of the cells used.
Adult stem cells, such as mesenchymal stem cells, are cheaper than embryonic stem cells, but the cost is still high. These procedures are also conducted in highly regulated and top-of-the-line labs and facilities, which further adds to the cost of the procedure.
Unlike a simple procedure for localized pain, the injection of stem cells for Parkinson’s disease is more complex, adding to the cost.
Does insurance cover MSC Therapy for Parkinson’s Disease treatment?
Currently, very few stem cell therapies are covered by insurance, and unfortunately, stem cell therapy for Parkinson’s disease is not one of them. However, you should consult various insurance providers to see what can be done.
How accessible is MSC Therapy for Parkinson’s Disease?
Since using stem cells to treat Parkinson’s disease is new, the therapy is not available as widely as some other stem cell therapies. It is also not available for patients at all Parkinson’s disease stages, as the results are better when treatment is undergone at an earlier stage.
But, there are still various places conducting this treatment that can produce promising results. You can find even more information about it by consulting experts at Swiss Medica Clinics.
What are the potential financial and logistical challenges of pursuing MSC Therapy for Parkinson’s Disease?
One of the biggest hurdles from a patient’s perspective is the cost of the therapy. It is also not a simple procedure that can be done in a single day and requires a lot of testing and follow-up visits.
Even if the cells are taken from the patient themselves, the procedures are rather complex and require a lot of technology, optimum storage, and working conditions to ensure the best results. The injection of these cells into the patient after being replicated is also a complex task and requires a lot of expertise. So, the procedure is only offered by a handful of reputable institutes.
Affordability and Accessibility of Mesenchymal Stem Cell Therapy for Parkinson’s Disease
Neurodegenerative diseases like Parkinson’s disease can be very difficult for both the patient and their family. But with advancements in science and new treatment options like stem cell therapy, there is hope for these patients.
Although the cost of stem cells to treat Parkinson’s disease are not minimal, the results can be rather promising. They can help improve the patient’s quality of life rather significantly. If you are in need of such a treatment, you can check out one of the most prominent clinics in this field, Swiss Medica in order to receive more information.
Rashmika Mandanna announces her next film Mysaa with a fierce first-look poster.
The image features Rashmika in a raw, never-seen-before warrior avatar.
Directed by Rawindra Pulle, the film is an emotional action thriller set in the Gond tribal world.
Rashmika called it her most intense role yet, saying it’s a version of herself she hadn’t met before.
Rashmika Mandanna has taken fans by surprise with the first look of her upcoming film Mysaa, revealing a fierce and gritty avatar unlike anything she’s done before. Shared on her social media, the poster hints at a powerful, raw performance, with Rashmika stepping into the shoes of a tribal warrior, a role she describes as “intense,” “unfiltered,” and “completely new.”
Clad in traditional attire with tribal jewellery, Rashmika’s character appears wounded but unbroken, clutching a bloodied weapon and wearing a fiery stare. The tagline on the poster reads, “Hunted. Wounded. Unbroken,” while another version teases: “Rashmika Unleashed.”
This is her first solo-led film and is expected to become a significant milestone in her career. Speaking about the project, Rashmika said: “It’s a version of me even I hadn’t met. I’m nervous and excited.”
The title and poster were launched with support from across industries, with actors like Dhanush, Vicky Kaushal, and Dulquer Salmaan sharing regional versions of the look to mark the pan-India release.
Mysaa is an emotional action thriller rooted in tribal culture
Directed by debutant Rawindra Pulle and produced by Unformula Films, Mysaa explores the world of the Gond tribes through an action-packed, emotionally rich narrative. Pulle revealed the film took two years to develop, with a strong focus on authenticity and world-building.
Following her recent success with Kuberaa, Rashmika is on a roll in 2025. Alongside Mysaa, she’s working on the horror-comedy Thama with Ayushmann Khurrana, The Girlfriend, Rainbow, and will reprise her role in Pushpa 3.
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ASDA, one of Britain’s largest supermarkets, has reported a pre-tax loss of £599 million for 2024, swinging sharply from a £180 million profit the previous year.
The loss comes despite total sales rising by over £1 billion to £26.8bn, as the retailer faces mounting debt costs, falling sales, and spiralling spending on a major IT overhaul, the Telegraph reported.
The main blow to Asda’s finances has come from its heavy debt load, a legacy of its £6.8bn buyout by the Issa brothers and private equity firm TDR Capital in 2021.
According to the report, the company’s debt pile, now close to £5bn, has become much more expensive to service as interest rates have risen. Last year, finance costs jumped by 38 per cent to £611 million, up from £441 million the previous year
Asda said it was forced to pay higher rates after refinancing part of its debt, putting further pressure on its bottom line.
Another major factor behind the loss is the ongoing “Project Future” – Asda’s multi-year plan to separate its computer systems from former owner Walmart. The project has been beset by delays and cost overruns, with total spending now approaching £1bn, far above its original budget
Last year alone, Asda spent £310m on the IT transition, which has included job cuts and outsourcing as the company tries to control costs. Problems with the new systems have also led to pay errors for thousands of staff.
While overall revenue rose thanks to new store openings, underlying sales have slipped. Like-for-like sales, excluding fuel, fell by 3.4 per cent to £21.7bn, with food sales down 3.7 per cent.
Meanwhile, Asda’s share in the UK grocery market has dropped to a record low of 12.1 per cent, with the retailer losing ground to rivals such as Tesco, Aldi, and Lidl
Despite efforts to win back shoppers with price cuts and a new convenience store push, Asda was the only major supermarket to report a sales decline in recent months, analysts said.
The company’s results were also hit by a £378m impairment charge, reflecting a drop in the value of its stores and assets. These one-off costs, combined with the IT spending, were singled out by Asda as the main reasons for the headline loss.
“The reported overall loss is the result of two significant one-off costs,” an Asda spokesman said, pointing to the impairment and Project Future costs. “These are not recurring costs and do not reflect the underlying performance of the business”
Allan Leighton, who returned as chairman last year, has launched a price war and cost-cutting drive to try to restore Asda’s fortunes. He has described many of the company’s problems as “self-inflicted” and is aiming to “turn it into what it was”. However, he has warned that a full recovery could take several years.
Despite the bleak headline numbers, Asda insists its core business remains profitable, with a pre-tax profit of £115m before exceptional items. Adjusted earnings before rent also rose slightly to £1.14bn.
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A total of 126 Labour MPs had publicly supported a move to block the proposals, marking the biggest rebellion under Starmer’s leadership so far. (Photo: Getty Images)
THE GOVERNMENT has backtracked on plans to reduce disability and sickness benefits following a major rebellion by MPs from within the Labour Party.
Care minister Stephen Kinnock confirmed on Friday that concessions had been made to address concerns raised by lawmakers who opposed the proposed reforms. This comes just days after prime minister Keir Starmer had said he would continue with the changes.
A total of 126 Labour MPs had publicly supported a move to block the proposals, marking the biggest rebellion under Starmer’s leadership so far.
A spokesperson for the prime minister’s Number 10 office said, “The government had listened to MPs who support the principle of reform but are worried about the pace of change for those already supported by the system.”
The spokesperson added that a revised set of measures would maintain support for those “who need it, by putting it on a sustainable footing.”
Changes to be announced in parliament
Kinnock said the concessions, which will be presented in parliament later, would include a “staggered approach” to the reforms.
This change means that the stricter eligibility criteria originally proposed will now apply only to new claimants and not to people who are already receiving benefits.
“What's clear from the announcement today is that it's going to be a more staggered process whereby people who are existing claimants are protected,” Kinnock said.
The reversal comes near the end of the Starmer government’s first year in office. The Labour Party came to power after defeating the Conservatives in a general election held on July 4, 2024.
Kinnock said he was now confident that the Universal Credit and Personal Independence Payment (Pip) Bill, which includes the reforms, would pass a parliamentary vote scheduled for Tuesday.
The government had aimed to save £5.0 billion through the proposed changes, which have now been partly rolled back.
Chancellor Rachel Reeves is continuing efforts to stimulate growth in the UK’s slow economy.
THE Delhi High Court has refused immediate relief to a man whose wife Harshita Brella was murdered in the UK, after he approached the court fearing arrest on domestic cruelty charges.
The vacation bench of justices Pratibha M Singh and Rajneesh Kumar Gupta heard the petition from Pankaj Lamba, who was challenging a magistrate's May 1 order declaring him a proclaimed offender.
The court told Lamba he could use legal remedies in accordance with the law if arrested, but said the case should be heard by the regular court as various legal issues were involved.
Harshita Brella's body was discovered in the boot of a car in east London on November 14, 2024. The car belonged to her husband Lamba and was parked in Brisbane Road, Ilford.
Brella's family claimed it was a planned murder, alleging that Lamba managed to flee to India just one day after killing his wife.
Her family filed a complaint at Palam village police station on November 19 last year. A case against Lamba and other family members was registered on December 3 under sections of the Indian Penal Code including cruelty to a married woman, criminal breach of trust and common intention.
In an order on June 18, Justice Pratibha M Singh noted: "The FIR dated December 3, 2024, against the petitioner has been registered under Sections 498A, 406 and 34 of the IPC, according to which his wife, Harshita Brella is stated to have died under mysterious circumstances in the United Kingdom."
The court said the matter required consideration as various legal issues had been raised. It noted that Lamba's father was already in custody.
"List this matter before the regular court on July 15. If the petitioner is arrested in the meantime, he may avail his legal remedies in accordance with the law," the court ordered.
His parents, Darshan Singh and Sunil Devi, were arrested on March 19 this year in connection with the case. Lamba had expressed fear of arrest in the case registered at Palam Vihar police station, but the court said the matter should be heard by the regular bench rather than the vacation court.
(PTI)
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The 30-year-old fast bowler has struggled with injuries throughout his career and has played just 13 Tests, the last of which was in February 2021.
JOFRA ARCHER has been named in England's squad for the second Test against India, marking his return to the Test side after more than four years.
The 30-year-old fast bowler has struggled with injuries throughout his career and has played just 13 Tests, the last of which was in February 2021.
Archer last appeared for England in March during a one-day international against South Africa at the ICC Champions Trophy in Pakistan.
He returned to first-class cricket on Sunday, playing for Sussex for the first time in four years. He took one wicket in a drawn match against Durham.
Speaking to the BBC, Archer said it had been a mental challenge to return to red-ball cricket but confirmed he was ready for Test matches.
"Yeah. I guess so," he said. "I just want to get through the game. I'm glad I've finished a day of four-day cricket."
England won the first Test at Headingley on Tuesday with a five-wicket victory over India. Archer was added to the squad on Thursday as the only change ahead of the second Test in Birmingham.
Archer, who was born in Barbados, made an immediate impact after his debut in 2019, providing England with pace and accuracy. He bowled the decisive super over in the World Cup final against New Zealand that year and later took 22 wickets in four Tests during the Ashes series against Australia, which ended in a draw.
Since then, he has dealt with recurring injuries. An elbow injury first suffered in 2020 required multiple surgeries. He also had to recover from a stress fracture in his back in 2022.
He was recently ruled out of England's ODI series against the West Indies due to a thumb injury sustained while playing for Rajasthan Royals in the Indian Premier League.
Archer has taken 42 wickets in 13 Tests at an average of 31.
Jacob Bethell, Sam Cook and Jamie Overton, who were part of the squad for the first Test but did not play, have retained their places for the second Test at Edgbaston, which begins on July 2.
England squad: Ben Stokes (capt), Jofra Archer, Shoaib Bashir, Jacob Bethell, Harry Brook, Brydon Carse, Sam Cook, Zak Crawley, Ben Duckett, Jamie Overton, Ollie Pope, Joe Root, Jamie Smith (wkt), Josh Tongue, Chris Woakes.