Oxford University steroid ‘breakthrough’ raises hopes amid Asian quagmire


In this photo illustration, a close-up of a box of Dexamethasone tablets in a pharmacy on June 16, 2020 in Cardiff, UK. Results of a trial have shown that Dexamethasone, a cheap and widely used steroid drug which is used to reduce inflammation, reduced death rates by around a third in the most severely ill Covid-19 patients. (Photo: Matthew Horwood/Getty Images)
In this photo illustration, a close-up of a box of Dexamethasone tablets in a pharmacy on June 16, 2020 in Cardiff, UK. Results of a trial have shown that Dexamethasone, a cheap and widely used steroid drug which is used to reduce inflammation, reduced death rates by around a third in the most severely ill Covid-19 patients. (Photo: Matthew Horwood/Getty Images)

THE World Health Organization on Tuesday (16) hailed a UK-led “breakthrough” steroid treatment for the coronavirus, boosting hopes that pandemic deaths can be reduced, but a growing new cluster in China sparked fears of a second wave of infections.



Surging death tolls in the Americas and South Asia, plus a new cluster of cases in Beijing, have raised fresh doubts about how soon the world can bring Covid-19 under control.

In the latest sign of the economic toll, US Federal Reserve Chair Jerome Powell warned that the world’s biggest economy is unlikely to recover as long as there is “significant uncertainty” about the pandemic.

But news of the first proven effective treatment for Covid-19, a widely available steroid, gave cause for fresh hope.



“This is great news and I congratulate the government of the UK, the University of Oxford, and the many hospitals and patients in the UK who have contributed to this lifesaving scientific breakthrough,” said WHO chief Tedros Adhanom Ghebreyesus.

British Prime Minister Boris Johnson hailed the government-funded trial as the “biggest breakthrough”, which “greatly reduced” patients’ chances of dying due to Covid-19.

“I am proud of these British scientists, backed by UK government funding, who have led the first, robust clinical trial anywhere in the world to find a coronavirus treatment proven to reduce the risk of death,” he said.



Researchers led by a team from the University of Oxford administered the drug, dexamethasone, to more than 2,000 severely ill Covid-19 patients.

Among those who could only breathe with the help of a ventilator, it reduced deaths by 35 per cent.

“Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide,” said Peter Horby, professor of Emerging Infectious Diseases in the Nuffield Department of Medicine at Oxford.



Trial results announced showed dexamethasone, which is used to reduce inflammation in other diseases such as arthritis, reduced death rates by around a third among the most severely ill Covid-19 patients.

Britain’s health ministry wasted no time, saying the drug had been approved for use in the state-run health service, export restrictions had been introduced and 200,000 courses of the treatment had been stockpiled.

“This is a (trial) result that shows that if patients who have Covid-19 and are on ventilators or are on oxygen are given dexamethasone, it will save lives, and it will do so at a remarkably low cost,” said Martin Landray, an Oxford University professor co-leading the trial, known as the RECOVERY trial.

“For less than £50, you can treat eight patients and save a life,” he said in an online briefing. One death would be prevented in every 25 Covid-19 patients on oxygen that received the drug, he calculated.

Britain’s Health Secretary Matt Hancock said patients would start to receive the drug immediately.

“It does increase your chances of survival quite significantly,” Health Secretary Matt Hancock told Sky News. “It is one of the best pieces of news we’ve had through this whole crisis.”

Chinese cluster, Indian spike

But there were fresh reminders of the lingering threat from Asia.

China, which had largely brought its outbreak under control, reported another 31 new infections in Beijing, bringing the total from a fresh cluster linked to a wholesale food market to 137 in six days.

The capital’s airports cancelled at least 1,255 flights Wednesday, nearly 70 per cent of all services, state media reported.

The new outbreak has led authorities to implement mass testing, put neighbourhoods on lockdown, close schools and urge residents to not to leave the city.

And in India, the world’s second-most populous country, saw its Covid-19 death toll shoot up by more than 2,000 to nearly 12,000 fatalities.

More than 8.1 million people have now been infected by the virus since it emerged in China late last year, with nearly 440,000 deaths so far.

Brazil, which has the second-highest caseload and death toll in the world, reported its biggest daily jump in new cases since the start of the pandemic: 34,918.

Peru’s death toll, meanwhile, surged past 7,000.

And the US, the hardest-hit country, passed a grim milestone: with 116,854 deaths, the country has now seen more people die from the pandemic than in World War I.

Fed chief Powell once again pledged the bank will use all its policy tools to help ensure recovery from the outbreak, which he said has inflicted the worst pain on low-income and minority groups.

But the economic contraction in the April-June quarter “is likely to be the most severe on record,” he said.

Beyond the Americas, Iran and Saudi Arabia have all reported sharp increases in deaths and infections in recent days.

Fans, please stay away

European nations including Belgium, France, Germany and Greece have begun lifting border restrictions, hoping to save the summer tourism season.

But life is still far from normal.

In Britain, the Premier League football season resumes on Wednesday, but in empty stadiums.

The league urged supporters not to congregate outside the grounds, risking new clusters of infections.

It plans to pipe crowd chants into stadiums, place cardboard cut-outs of supporters in the stands and use live video fan walls, but in the words of Manchester City manager Pep Guardiola, things risk being “a little bit weird”.