Blood test could predict dementia ten years before onset
Currently, brain scans can detect abnormal levels of a protein called beta amyloid many years before Alzheimer's dementia develops, but the tests are costly
By Eastern Eye Mar 02, 2024
A STUDY of frozen blood samples has turned up a trove of proteins that may predict several forms of dementia more than 10 years before the disease is diagnosed, researchers from the UK and China reported last month.
The study, published in the journal Nature Aging, is part of ongoing research from multiple teams to identify patients at risk for dementia using a simple blood test, an advance many scientists believe will accelerate the development of new treatments.
Currently, brain scans can detect abnormal levels of a protein called beta amyloid many years before Alzheimer’s dementia develops, but the tests are costly and often not covered by insurance.
“Based on this study, it does seem likely that blood tests will be developed that can predict risk for developing dementia over the next 10 years, although individuals at higher risk often have difficulty knowing how to respond,” said Dr Suzanne Schindler, an Alzheimer’s researcher at Washington University in St Louis, who was not involved in the research.
Study author Jian-Feng Feng of Fudan University in Shanghai said such tests are critical in ageing populations such as China’s, and noted that he is in talks for the potential commercial development of a blood test based on their research.
In the study, researchers at the University of Warwick and Fudan University studied 52,645 blood samples from the UK’s Biobank research repository, collected between 2006 and 2010, from people who had no signs of dementia at the time.
Of these, 1,417 people eventually developed Alzheimer’s disease, vascular dementia, or dementia from any cause. The researchers studied protein signatures common in these individuals and turned up 1,463 proteins associated with dementia and ranked these according to how likely they were to predict dementia.
They found that people whose blood carried higher levels of the proteins GFAP, NEFL, GDF15 and LTBP2 were consistently more likely to have developed Alzheimer’s disease, vascular dementia, or dementia from any cause. They aslo found that people with elevated levels of GFAP were 2.32 times more likely to develop dementia, confirming findings from smaller studies that had pointed to the contribution of this protein.
The authors noted that their research has not been independently validated.
One protein that performed well in predicting dementia, neurofilament light, is already used in the clinic for diagnosing and monitoring some conditions, such as multiple sclerosis, Schindler said in an email.
“This study did not include clinically available blood tests for Alzheimer disease, which may even better predict development of dementia due to Alzheimer’s disease,” she said.
Such tests are already being used in identifying candidates for clinical trials testing treatments in patients with early-stage or even presymptomatic disease, such as Eisai and Biogen’s Leqembi. (Reuters)
Chinese dim sum restaurant Ping Pong has closed all its UK locations
The chain made the announcement via social media
Founded in 2005, the brand thanked customers and staff for their support
Loyal diners shared memories and disappointment in the comments
All branches are permanently closed
Chinese restaurant chain Ping Pong has permanently closed all its branches in the UK, the company confirmed in a social media announcement.
Founded in 2005 by restaurateur Kurt Zdesar, the dim sum chain had become popular for its stylish interiors, creative menus, and Asian-inspired cocktails. The company did not provide prior notice of the closure but said the decision marked the end of an “unforgettable” 20-year journey.
Social media announcement thanks customers and staff
In a post shared on Instagram, the company wrote: “It’s a wrap. After 20 unforgettable years, all Ping Pong locations are now permanently closed.
“We’re incredibly proud of what we built, an independent hospitality brand full of creativity, flavour and soul.
“To everyone who joined us over the years, for dim sum dates, happy hours, bottomless brunches, and just-because catch-ups – thank you.
“You shared your moments with us, passed around little parcels of deliciousness, and helped make Ping Pong what it was.
“To our collaborators, suppliers, and the incredible team who kept the steam going, thank you. It’s been sum-thing truly special.”
Customers express sadness over sudden closure
Regular customers responded to the announcement with disappointment and nostalgia. Many expressed shock over the sudden news and the lack of notice.
One Instagram user commented: “Noooo, we’ve made some amazing memories there, birthdays, anniversaries, you name it. The food was always so amazing.”
Another said: “WHAT?? WE HAD NO CHANCE TO SAY GOODBYE! NO WARNING.”
Others fondly recalled the restaurant’s atmosphere and signature dishes, with one writing: “The food and the lychee cocktails will be sorely missed.”
Ping Pong had multiple locations across London and was known for its contemporary take on traditional Chinese dim sum. The chain had also gained a following for its themed brunches, casual dining experience, and cocktail offerings.
No further information has been shared regarding the reason behind the closure or whether the brand will return in a new format.
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Experts have raised concerns about the immune-evasive nature of the Stratus strain
A new Covid strain known as Stratus is spreading across the UK
The variant is marked by a distinctive symptom: a hoarse or raspy voice
Sub-variants XFG and XFG.3 now account for 30% of cases in England
Experts say there is no evidence of more severe disease
Lower immunity levels may make more people vulnerable to infection
Covid variant Stratus on the rise in the UK
A new strain of Covid-19, known as Stratus, is spreading across the UK and drawing attention for its unusual symptom — a hoarse or raspy voice. According to data from the UK Health Security Agency (UKHSA), Stratus and its two sub-variants, XFG and XFG.3, are responsible for around 30 per cent of Covid cases in England.
Of the two, XFG.3 is currently the more dominant. The UKHSA confirmed that monitoring of all circulating Covid-19 variants is ongoing as part of regular surveillance.
Mutations help Stratus spread despite immunity
Experts have raised concerns about the immune-evasive nature of the Stratus strain. Dr Kaywaan Khan, a Harley Street GP and founder of Hannah London Clinic, noted that certain mutations in the spike protein could help the virus bypass antibodies generated by previous infection or vaccination.
“Unlike other variants, Stratus has certain mutations in the spike protein which could help it evade antibodies developed from prior infections or vaccinations,” said Dr Khan. However, the symptoms tend to remain mild to moderate, with hoarseness being one of the most noticeable.
Dr Alex Allen, Consultant Epidemiologist at the UKHSA, said, “It is normal for viruses to mutate and change over time,” adding that there is currently no evidence that the XFG or XFG.3 variants cause more severe disease than previous strains.
Waning immunity raises infection risk
According to Professor Lawrence Young, a virologist at the University of Warwick, the reduction in Covid-19 infections in recent months, along with lower booster jab uptake, could increase the risk of infection.
“Given that immunity to Covid is waning in the population due to a decline in uptake of the spring booster jab and the reduction of Covid infections in recent months, more people will be susceptible to infection with XFG and XFG.3,” he told MailOnline.
He warned that this could lead to a new wave of infections, though the scale remains uncertain.
Global monitoring of the strain
Globally, Stratus accounted for 22.7 per cent of Covid cases as of 22 June, according to the World Health Organisation (WHO). The strain has been designated as a “variant under monitoring”, with WHO currently assessing its public health impact as low risk.
The emergence of Stratus follows the spread of another recent variant called Nimbus (NB.1.8.1), first detected in China and Hong Kong in January and now present in parts of the US and Australia. Nimbus has been associated with more severe sore throat symptoms.
Reduced testing levels since the pandemic’s peak make it difficult to track the true spread of these new variants, health officials have noted.
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Sophie, Duchess of Edinburgh, who grew up in Brenchley
Day one of the Kent County Show begins at Detling Showground near Maidstone
The Duchess of Edinburgh visits the event for the first time in 16 years
Organisers expect up to 70,000 visitors over the weekend
Farming and rural life are at the centre of the three-day programme
Highlights include live camel racing, equine sports, livestock displays and more
Kent County Show opens with royal visit
The Kent County Show returned to Detling near Maidstone on Friday, marking the start of a major three-day celebration of farming, food, and rural living. The event opened with a special visit from the Duchess of Edinburgh, who is attending for the first time in 16 years.
Sophie, Duchess of Edinburgh, who grew up in Brenchley near Tunbridge Wells and serves as patron of the Association of Show and Agricultural Organisations (ASAO), met with farmers, equine exhibitors, and local businesses on her tour of the showground.
Spotlight on farming and rural life
Organised by the Kent County Agricultural Society, the show brings together people from across the county to highlight the importance of agriculture and rural industries. Chairman Matthew Cullen said there was a "real buzz in the air" and called the royal visit a “great achievement”.
“There’s lots on offer,” he said. “From the livestock section with all the animals, young farmers, equine sports and food halls. We’ve also got something a little unusual this year – live camel racing. It isn’t what you’d normally get to see.”
Mr Cullen added that the event offers an opportunity for farmers to network and for the public to better understand how food is produced. “We all know Kent as the Garden of England, so for the rural and farming sector, it's a proud moment to come together and show off to the general public.”
Boost in interest following farming TV series
According to Mr Cullen, the farming sector has seen a noticeable spike in public interest, partly due to the popularity of the Amazon Prime series Clarkson’s Farm. “It has brought farming to the forefront of people’s minds,” he said, noting a broader uptick in engagement at agricultural shows across the UK.
— (@)
Friday highlights at the showground
The opening day features a packed programme of events across multiple rings. Highlights include:
09:30 – Kent Youth Trials (Heritage Ring)
10:00 – Joseph’s Amazing Racing Pigs (Countryside Ring)
11:15 – Camel Racing (John D Wood & Co Astor Ring)
11:45 – Sheep Dog Display (Countryside Ring)
12:15 – Hypo Hounds Diabetic Assistance Dog Display (Countryside Ring)
13:15 – Heritage Parade (John D Wood & Co Astor Ring)
15:05 – British Novice Showjumping with 90cm Open (Standen Ring)
17:30 – Donkey In Hand Championship (Pam Nesfield Ring)
Performances from Rock Choir and various vehicle and dog displays are also scheduled throughout the day.
Visitor information and tickets
Attendance for the weekend is expected to range between 60,000 to 70,000 people, depending on the weather. Tickets are still available to book online or can be purchased at the gate.
Adult tickets: £22 (in advance)
Child tickets: £3 (in advance)
Under 5s: Free entry
The Kent County Show continues through the weekend with a wide range of attractions, from local produce to equestrian competitions and entertainment for all ages.
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Heehs’s biography is grounded in extensive archival research across France, England, India and Israel
My friend and colleague, the American historian Peter Heehs, who has lived in Pondicherry, India, for decades, recently published a compelling new biography, The Mother: A Life of Sri Aurobindo’s Collaborator (2025). Heehs previously authored The Lives of Sri Aurobindo (2008), which remains one of the most balanced and scholarly accounts of Aurobindo’s life.
According to Heehs, most previous biographies of the Mother were written for devotees and relied on secondary sources, often presenting her as a divine incarnation without critical engagement. “Such biographies are fine for those who see the Mother as a divine being,” Heehs said, “but they can be off-putting for readers who simply want to understand her life – as an artist, writer, spiritual teacher, and founder of the Ashram and Auroville.”
Heehs’s biography is grounded in extensive archival research across France, England, India and Israel, along with digital collections of historical newspapers and journals. He examined all of her published works in both French and English, even uncovering essays written under a pseudonym that had not been seen since 1905. He traces her early life within the vibrant world of Belle Époque Paris (1871–1914), where she moved in artistic and esoteric circles.
Heehs describes two principal approaches to biographyAMG
Born in 1878 into a moderately wealthy Sephardic Jewish family – her father was Turkish-Egyptian, her mother Egyptian-Jewish – Mirra Alfassa grew up in an intellectually rich and cosmopolitan environment. Tutored at home, she later studied painting at the prestigious Académie Julian and exhibited at the Paris Salon. Her first husband, Henri Morisset, was a painter of the Intimist school, more traditional than contemporaries like Henri Matisse, Édouard Vuillard and Pierre Bonnard. Though he never gained their level of fame, he moved in similar artistic circles, and Mirra herself knew and associated with figures like Auguste Rodin.
At the same time, she was deeply engaged in the French occult revival, serving as managing editor of the Revue Cosmique, an esoteric journal. Her spiritual journey intensified when she encountered the Bhagavad Gita under the guidance of Indian lecturer G N Chakravarty and later engaged with eastern spiritual teachers such as Inayat Khan and ‘Abdu’l-Bahá.
In 1910, her second husband, Paul Richard, travelled to Pondicherry and met Sri Aurobindo. In 1914, Mirra joined him in India, and together with Aurobindo, they launched the monthly review Arya, which published most of Aurobindo’s major writings. The First World War forced their return to France, followed by a sojourn in Japan. They returned to Pondicherry in 1920, after which Paul Richard departed. Mirra remained and became Aurobindo’s closest spiritual collaborator.
Heehs describes two principal approaches to biography. The first – the contingent approach – follows the subject’s life chronologically, attending closely to verifiable facts. The second – the teleological approach – interprets the subject’s life as an inevitable progression towards a destined goal. “I took the contingent approach when dealing with the Mother’s early life,” Heehs explained, “and continued to do so even after Sri Aurobindo declared her to be an incarnation of the divine Shakti. As a historian, my role is not to make theological pronouncements but to present the facts of her outer and inner life, insofar as she spoke about them.”
When asked about the Mother’s lasting contributions, Heehs emphasised: “She established the Sri Aurobindo Ashram, founded its school – the Sri Aurobindo International Centre of Education – and launched the international utopian city of Auroville. At the same time, she oversaw both the inner and outer lives of the ashram’s members.”
Aurobindo Ackroyd Ghosh – the polymath Indian philosopher, freedom fighter and revolutionary yogi – was educated in England at St Paul’s School and King’s College, Cambridge, where he was trained in the Classics. Long before the term “Asian century” became popular, Aurobindo had already envisioned Asia’s re-emergence on the world stage. Today, countless volumes have been written about his extraordinary life and complex philosophical legacy.
Although it may sound like a modern geopolitical thesis, Aurobindo proclaimed in 1918: “Asia is once more rising; she is throwing off the torpor of centuries. She is recovering the pride of her past and the faith in her future... It is through the recovery of the deeper self of Asia that the world will find its balance.”
His collaborator, Mirra Alfassa, widely known as the Mother, dedicated her life to actualising this prophetic vision.
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Tesco has issued an urgent product recall for two batches of Wall’s Scotch Eggs
Tesco and the Food Standards Agency (FSA) have issued an urgent recall for Wall’s Scotch Eggs.
Salmonella contamination has been confirmed in two batches with a use-by date of July 2, 2025.
Customers are advised not to eat the affected items and return them to any Tesco store for a full refund.
No other Wall’s products are affected by this recall.
Wall’s Scotch Eggs recalled due to salmonella risk
Tesco has issued an urgent product recall for two batches of Wall’s Scotch Eggs after salmonella contamination was confirmed. The Food Standards Agency (FSA) supported the decision and has advised customers to check their kitchens and dispose of or return the products immediately.
The recall applies specifically to Wall’s 2 Classic Scotch Eggs 226g and Wall’s The Classic Scotch Egg 113g, both with a use-by date of 2 July 2025. Customers who purchased either product are urged not to consume them due to the potential health risk.
Symptoms and safety guidance
Salmonella is a bacteria that can cause food poisoning, with symptoms including fever, diarrhoea, and abdominal cramps. The FSA and NHS advise that anyone experiencing these symptoms after eating a recalled item should seek medical advice if necessary.
Customers are advised to avoid eating the affected products and return them to any Tesco store for a full refund, with no receipt required. Point-of-sale notices have been displayed in all stores that stocked the affected items to alert customers to the issue.
Tesco and manufacturer issue statements
Tesco confirmed the recall on its website and through in-store notices. The supermarket stated:
"Wall’s is recalling various Classic Scotch Eggs with the use-by date of 2 July 2025. This is due to the presence of salmonella."
The manufacturer, The Compleat Food Group, described the recall as a voluntary precaution, citing a "potential risk of salmonella." However, Tesco confirmed that the affected products sold in its stores were contaminated.
A spokesperson for The Compleat Food Group said:
"This is an isolated incident and no other Wall’s products are affected."
What to do if you’ve bought the product
Customers who have purchased the affected Wall’s Scotch Eggs are asked to:
Not consume the product.
Return it to any Tesco store for a full refund.
No proof of purchase is needed.
Additional information and support are available through the Wall’s website atwalls-pastry.co.uk or by contacting Tesco Customer Services on 0800 505 555. Customers can also email customercare@compleatfood.com for assistance.
To find the nearest Tesco branch, shoppers can use the store locator tool available on the Tesco website.
FSA guidance on food recalls
The FSA explained why recalls such as this one are issued:
"If there is a problem with a food product that means it should not be sold, then it might be 'withdrawn' or 'recalled'."
In this case, the FSA has issued a Product Recall Information Notice to alert both consumers and local authorities. It added that in some instances, a 'Food Alert for Action' is also issued to ensure the appropriate steps are taken.
This latest recall follows a recent series of food safety alerts, as salmonella was also detected in other snacks sold across England, Scotland, and Wales in the past week.