A team of scientists from Harvard Medical School has made a significant breakthrough in the field of aging by identifying a combination of drugs that can reverse the aging process within a week.
The treatment involved administering three different drugs to mice: growth hormone, Metformin, and a drug that activates the enzyme AMPK, Business Today reported.
Adenosine 5′ monophosphate-activated protein kinase (AMPK) serves as the body's "master regulator of energy metabolism" due to its role as an energy sensor within our cells.
As we age, researchers have observed a notable decline in AMPK activity.
This decrease in AMPK activity is believed to be one of the factors contributing to changes in appetite, body weight, energy levels, and other metabolic processes experienced as we grow older.
The study showed rejuvenation in aged muscles, liver tissue, and other organs.
Harvard researcher David Sinclair shared the discovery on Twitter and in the medical journal Aging.
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The findings have garnered widespread attention, with Sinclair's explanation of the findings receiving over one million views.
Further research conducted by a genetics professor and his team at Harvard Medical School involved developing chemical cocktails containing agents known for their treatment of various disorders.
The research spanned over three years and successfully identified molecules that can reverse cellular aging and revive human cells.
“We’ve previously shown age reversal is possible using gene therapy to turn on embryonic genes,” Sinclair tweeted.
David Sinclair recently spoke at the India Today Conclave 2023, emphasising the importance of identifying biological switches that control the aging process - Image Credit: Twitter
He added, “Now we show it’s possible with chemical cocktails, a step towards affordable whole-body rejuvenation."
This discovery offers promising rejuvenation possibilities in combating the effects of aging in humans.
Sinclair recently spoke at the India Today Conclave 2023, emphasising the importance of identifying biological switches that control the aging process.
He believes that manipulating these switches could potentially reverse aging effects and extend lifespan.
Sinclair's groundbreaking research has challenged traditional perspectives on aging, offering hope for future anti-aging therapies.
Sainsbury’s will roll out Your Nectar Prices to physical checkouts nationwide from 25 July.
Scheme gives loyalty members access to personalised discounts based on shopping habits.
Over 17 billion tailored offers generated since launch; £60m saved by customers in the last year.
More than one million shoppers currently use the feature weekly.
Offers now available in-store, online, via app, and soon, at checkout.
Sainsbury's brings personalised loyalty savings directly to the tills
Sainsbury’s will extend its Your Nectar Prices programme to checkouts across the UK starting Friday, 25 July. The move allows Nectar members to receive personalised discounts directly at the tills for the first time, as part of the retailer’s continued investment in digital loyalty.
The supermarket has already issued over 17 billion tailored offers since launching the scheme, with more than one million customers using it weekly. According to the retailer, these offers have helped shoppers collectively save £60 million over the past year.
Previously, Your Nectar Prices was available only through the SmartShop app, Sainsbury’s website, and the Nectar app. Now, with the expansion to checkouts, the scheme becomes more accessible to in-store customers.
How it works
To take advantage of the Your Nectar Prices discounts, customers must be digitally registered with Nectar. Each Friday, users need to “tap to unlock” their personalised deals via the Nectar app or website. Once activated, the offers are automatically applied at checkout – in-store or online.
Shoppers can receive up to 10 tailored discounts per week, based on their regular buying habits. Sainsbury’s estimates these could amount to savings of over £150 annually per customer.
A key milestone in loyalty personalisation
Mark Given, Chief Marketing, Data & Sustainability Officer at Sainsbury’s, commented on the expansion:
“Over the past few years, we’ve made significant strides with Nectar, with Nectar Prices being a big part of that success, bringing great value to millions of customers.
But what really sets us apart is that we’re leading the way by making loyalty personal. Shoppers want to feel recognised and rewarded and while Nectar Prices are for everyone, we know our customers love an offer that is made just for them.”
“Every week over a million customers are making the most of their personalised discounts and, by rolling this out to our checkouts, we’re opening the door for millions more to grab fantastic offers on the items they already purchase and maybe even discover some new favourites.”
Part of the wider Sainsbury Nectar Prices strategy
The rollout is part of Sainsbury’s broader Nectar Prices strategy, which offers savings on thousands of everyday items to all Nectar cardholders. The retailer encourages customers to use both the standard and personalised offers for maximum benefit.
Your Nectar Prices, launched four years ago, covers a wide range of categories including fresh food, household essentials, health & beauty, baby items, and pet care.
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The Palm House, along with the neighbouring Waterlily House, will be transformed
Kew Gardens will shut its iconic Palm House for up to four years
Grade I-listed building to undergo major restoration as part of net-zero strategy
Gas boilers to be replaced with modern heat pumps
Rare plant collection, including 45 endangered species, to be relocated during works
Palm House and Waterlily House will become the first net-zero glasshouses globally
Historic Palm House to undergo major upgrade
Kew Gardens will temporarily close one of its most recognisable landmarks, the Grade I-listed Palm House, for up to four years as part of an ambitious net-zero redevelopment plan. Opened in 1848, the glasshouse is home to a globally significant collection of tropical plants and houses the world’s oldest potted plant—an Encephalartos altensteinii dating back to 1775.
The Palm House, along with the neighbouring Waterlily House, will be transformed into the world’s first net-zero glasshouses through a large-scale renovation focused on improving energy efficiency and reducing carbon emissions.
Plans to modernise historic infrastructure
The project, submitted last week to Richmond-upon-Thames borough council, will replace ageing gas boilers—installed more than 100 years ago—with modern heat pumps. These upgrades are designed to help Kew Gardens meet its sustainability targets while preserving the conditions required to house rare tropical species.
Each pane of glass in the structure will be removed and recycled. New, more robust glazing will be fitted using advanced sealants designed to retain heat and humidity, crucial for plant survival.
The Palm House’s iron ribs will also be stripped, repaired and repainted in the original colour used when the structure first opened.
Funding for the scheme will come from a combination of grants and private investment.
Protecting rare and endangered plant life
During the renovation, the entire plant collection—comprising towering palms, passion plants, and 45 species at risk of extinction—will be carefully relocated to temporary glasshouses to ensure their survival.
Tom Pickering, head of glasshouse collections at Kew, described the project as both a dream and a major responsibility. “The aim is to make the Palm House energy efficient while retaining all the magic of what it is today in terms of planting and horticulture,” he said.
Reviving a global icon with modern innovation
Richard Deverell, director of Kew Gardens, emphasised the urgency of the work, saying: “The Palm House and Waterlily House represented the latest in design and build at the time of their construction, but they are showing serious signs of deterioration and are not at all energy efficient.”
“Without urgent work, these iconic listed buildings and the vital tropical plants they protect are at risk of being lost forever,” he added.
Deverell called the project an “epic opportunity” to combine cutting-edge technology with heritage conservation. He said architects, engineers and Kew’s horticultural team have already spent years developing and testing the features that will help secure the buildings’ future.
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Singer Anne-Marie gave an open and emotional interview on BBC Radio 2
Anne-Marie discussed the challenges of motherhood and returning to work in music
Revealed struggles with postnatal anxiety and depression after birth of daughter Seven
Praised therapy as a crucial support tool and advised others to seek help
Shared insights into life with two young children and how routines have changed her
Confirmed she will perform at the Women’s Rugby World Cup opening ceremony on 22 August
Anne-Marie opens up about motherhood and mental health
Singer Anne-Marie gave an open and emotional interview on BBC Radio 2 this morning (16 July), speaking to Scott Mills about the mental and physical challenges she has faced after becoming a mother of two. The artist, known for hits including 2002 and Friends, reflected on the impact of motherhood on her mental health and creative life.
Returning to music while raising a family
Anne-Marie revealed that adjusting to life with two children while returning to the music industry has been “really difficult”. She is mother to daughter Seven, aged one, and a baby son who is just two months old.
“Getting back into music and being a mum has been really difficult,” she said during the interview. “Having a second one, it’s like the attention spread of the two is difficult.”
Despite the challenges, she described her children as “the most beautiful little things you’ve ever seen”, adding that moments of calm—such as looking at photos of them while they sleep—make the exhaustion feel worthwhile.
Anxiety and postnatal mental health
The singer spoke frankly about how she experienced intense anxiety after the birth of her first child. “I actually had anxiety so bad when I first had Seven and I didn’t want to be left alone,” she said.
Anne-Marie admitted that she had only been aware of postnatal depression, not postnatal anxiety, until experiencing it herself. She went on to say that her postnatal depression developed around six months after Seven’s birth.
The role of therapy and learning to ask for help
Anne-Marie highlighted the importance of therapy in her recovery. First starting sessions during lockdown, she said she had periods where she paused, particularly after making her third album, believing she no longer needed support. However, after becoming a mother, she returned to therapy and now attends weekly sessions.
“I’m sorry if you saw any of the interviews where I said I don’t need you anymore,” she joked, referring to her therapist. “Can I have you back?!”
She encouraged others to reach out, saying, “Therapy is my best friend. But also tell people, because I never asked for help, and that’s why I got so tired. People think that you’re sweet when you’re pretending to be okay.”
Speaking about the lifestyle shift, Anne-Marie described how routines have become a major part of her day-to-day life. “When I think about routines, it stresses me out. If I don’t do it right, it stresses me out,” she said. “And now I have to make three meals a day to make sure she’s good, you know? So it’s all just a massive change, and now I’m in a routine that’s my life.”
She also reflected on how her body and mind have changed since becoming a mother, saying, “I look different. I feel different. My brain is rewired. I swear everything has changed.”
Looking ahead: TV, sport and live appearances
Anne-Marie also spoke about her daughter recognising her on TV, recent performances at Glastonbury, and practising karate. She confirmed she will be performing at the Women’s Rugby World Cup opening ceremony, which takes place at the Stadium of Light in Sunderland on Friday 22 August.
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The Great British Sewing Bee is back for 2025, welcoming 12 new home sewers to the sewing room
Hosted by Sara Pascoe with judges Patrick Grant and Esme Young
12 contestants will compete across 10 themed sewing challenges
Each episode features a Pattern, Transformation, and Made to Measure challenge
Opening week focuses on shaping garments including pleats and circle skirts
Sewing Bee returns with a fresh cast of home sewing talent
The Great British Sewing Bee is back for 2025, welcoming 12 new home sewers to the sewing room. Host Sara Pascoe returns to guide the competition, alongside judges Patrick Grant and Esme Young, who will evaluate each contestant’s technical ability and creative flair.
Spanning 10 weeks, the series will feature themed challenges ranging from artistic and historical references to cultural inspirations like the 1920s and Korean fashion. Contestants will face the usual trio of tasks each week: a Pattern Challenge, a creative Transformation Challenge, and a Made to Measure Challenge where garments are tailored to real models.
This week’s theme centres on “creating shape”. Contestants must sew a tie-front blouse, transform a circle skirt into a new outfit, and design a pleated dress that fits perfectly. One sewer will be awarded Garment of the Week, while another will be eliminated.
The 2025 Sewing Bee line-up
Caz Age 59 | Staffordshire | Retired After retiring from the family printing business, Caz has devoted more time to sewing, which she began at age 11. She enjoys technical sewing, including French seams and topstitching.
Kit Age 24 | Manchester | Digital marketer Kit taught themselves to sew at school and returned to the hobby at university. They create one garment per week and are drawn to turning unusual fabrics into stylish pieces.
Gaynor Age 72 | Port Talbot, Wales | Retired office manager Gaynor has sewn since the 1950s and now teaches her granddaughter. Her style is described as smart and traditional.
Jess Age 33 | London | Head of communications Jess began sewing as a child to connect with her mother and grandmother. She resumed the hobby during lockdown and continues to create her own clothing.
Órla Age 19 | Inverness | Café worker and student The youngest contestant, Órla started sewing four years ago and enjoys experimenting with both androgynous and feminine looks. She dreams of building a self-made wardrobe.
Peter Age 45 | Devon | Senior pre-construction manager Peter took up sewing after watching the show with his daughters. He focuses on practical garments and enjoys upcycling, such as turning old jackets into bags.
Glendora Age 59 | Luton | Bus driver Glendora began sewing at eight and has since made over 30 quilts. She values durability and quality in her creations.
Yasmin Age 30 | Gateshead | Research and development scientist Yasmin learned to sew from her father, who inspired her to apply to the show. She honours his memory through her sewing, including a pink zebra dress they made together.
Novello Age 66 | London | Business owner and magistrate Inspired by Blue Peter, Novello began sewing at five and received her first machine at age seven. She enjoys creating unique and personalised garments.
Dan Age 37 | Durham | Performer Dan started hand-stitching garments at 10 and now uses his sewing skills to make costumes for stage performances.
Saffie Age 32 | London | Lecturer in Product and Industrial Design Taught to knit by her great-aunt at age eight, Saffie now creates a functional and stylish wardrobe using patterns from independent designers.
Stuart Age 53 | Herefordshire | Premises manager Stuart began sewing in 2020 intending to make hats but quickly expanded his repertoire. He combines practicality with creativity in his work.
How to watch
The Great British Sewing Bee 2025 airs weekly on BBC One, beginning Tuesday 15 July at 9pm.
Tune in to see which of these talented sewers will impress the judges and make it to the final.
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The event follows recent data from the Human Fertilisation and Embryology Authority (HFEA)
Event part of South Asian Heritage Month, taking place in London
Focus on fertility challenges faced by the South Asian community in the UK
Speakers include individuals with lived experience and reproductive health experts
HFEA data reveals ethnic disparities in IVF outcomes and patient satisfaction
Aims to break taboos, encourage open dialogue, and advocate for tailored care
Fertility event aims to spotlight inequalities and cultural stigma
A landmark event during South Asian Heritage Month will explore the unique fertility challenges faced by South Asian communities in the UK. Titled Breaking the Silence – Fertility Journeys in the South Asian Community, the event will take place in London on Tuesday 5 August from 5:30pm to 8:15pm.
The panel gathering will feature individuals with lived experience of infertility, baby loss and involuntary childlessness, alongside clinicians and mental health professionals specialising in reproductive care. The goal is to open up often-silenced conversations and address disparities in access to fertility treatment and patient outcomes among South Asian groups.
Ethnic disparities in fertility treatment outcomes
The event follows recent data from the Human Fertilisation and Embryology Authority (HFEA), which highlights troubling disparities in fertility treatment success. While overall IVF birth rates continue to improve, success rates for Asian patients remain lower. For those aged 18–37, the birth rate per embryo transferred is 27% for Asian patients and 25% for Black patients, compared with 33% for White patients.
The figures reflect long-standing concerns that ethnic minority patients do not receive the same quality of care or outcomes as others. Beyond clinical results, the HFEA’s National Patient Survey found that Black and Asian patients are less likely to report satisfaction with their fertility treatment.
Cultural barriers and need for tailored support
The panel event will tackle the cultural taboos and stigma often surrounding fertility within South Asian communities. Organisers hope the conversation will not only validate the emotional and social challenges many individuals face but also lead to meaningful action around culturally competent care.
Attendees will hear from those who have navigated complex fertility journeys, as well as professionals who are working to improve reproductive healthcare for ethnic minority communities. By fostering open dialogue, the event aims to break down barriers, increase awareness, and help bridge the gap in patient experience and outcomes.
Anita GuruInstagram/ _themindcoach_
More information
To attend or for further details, please get in touch with Anita Guru 📧 anita@fertilitynetworkuk.org 📞 07854 769761
For a detailed overview of the event, visit our website