There are many illnesses and ailments that can leave us feeling debilitated and interfere with the way we go about our daily lives. In fact, we all feel different kinds of physical pain in our lives from time to time.
However, certain conditions can cause severe pain which can affect our capacity and ability to carry out even daily tasks. If left untreated, such pain can take a toll on not just our physical health, but our mental health as well.
Besides, some of the health conditions that can cause pain are not very visible and therefore, may not be diagnosed for many years, making it very difficult to manage. And though there are many illnesses that produce pain, the NHS lists 20 such conditions that can be the most painful, The Sun reports.
Let’s take a look at this long list of the most painful conditions – mentioned in no particular order.
1. Appendicitis
The first sign of appendicitis is a sharp pain in the middle of the abdomen, which comes and goes. This condition occurs due to the swelling of the appendix which is attached to the wall of the gut. Experiencing pain in the lower right side of the stomach is one of the most common symptoms. The pain can get worse if you are walking, coughing, or pressing down on the area.
The pain can also get worse within hours and in severe cases, if the appendix bursts it can even be fatal. Therefore, this condition requires urgent surgery to remove the swollen appendix.
Some of the other symptoms linked to appendicitis is nausea, constipation, diarrhoea, fever, loss of appetite, or feeling sick.
2. Endometriosis
This painful gynaecological problem occurs when tissue that is the same as the lining that is present in the womb or uterus, starts to grow in areas such as the fallopian tubes and ovaries.
As there is nowhere for this excess tissue growth to go, it gets very painful when it begins to shed. Endometriosis affects women of all ages and though it can be managed, it cannot be cured.
Those suffering from this condition can experience painful and heavy periods. Some of the other common symptoms include feeling sick, pelvic pain, difficulty in conceiving, and pain after sex.
3. Arthritis
More than 10 million people in the UK have arthritis or similar conditions that affect the joints. Arthritis is a common painful condition that causes pain, stiffness, and inflammation of the joints. This disease can get worse with age.
Two of the most common types of arthritis are osteoarthritis and rheumatoid arthritis.
Sufferers of this condition experience constant and often incapacitating joint pain usually in the knees, hips, fingers, or wrists.
Arthritis pain often presents as a burning sensation or a dull ache. It is also often associated with stiffness in the joints and muscle aches and can increase gradually over time or come on suddenly.
4. Acute pancreatitis
Located behind the stomach, the pancreas is a small banana-shaped organ, that is part of the digestive system, informs a previous report in WalesOnline. Acute pancreatitis is the sudden swelling of the pancreas which is usually caused due to the presence of gallstones and alcohol abuse.
This condition which can be potentially fatal causes sudden severe abdominal pain and inflammation of the pancreas.
Acute pancreatitis is not the same as chronic pancreatitis, whereby the pancreas becomes permanently damaged due to inflammation over many years.
5. Stomach ulcers
Open sores that grow on the lining of the stomach are known as stomach ulcers or peptic ulcers. These sores can also develop just beyond the stomach in part of the intestine.
According to experts, pain occurs either when the stomach is empty or right after eating and the symptoms are the same as heartburn, indigestion, and severe hunger pangs. Sufferers of this condition also experience burning or pain in the upper stomach.
6. Fibromyalgia
This is a deliberating long-term condition that can cause widespread pain all over the body.
This condition which is also known as fibromyalgia syndrome (FMS) cause extreme tiredness, sleeping problems, muscle stiffness, increased sensitivity to pain, headaches, issues with mental processes, and irritable bowel syndrome (IBS).
According to the charity Fibromyalgia Action UK fatigue associated with fibromyalgia, "ranges from feeling tired to the exhaustion of a flu-like illness."
It states, "It may come and go and people can suddenly feel drained of all energy – as if someone just 'pulled the plug'."
Fibromyalgia is supposedly linked to the brain's ability to process pain signals and this causes the body to amplify painful sensations. It occurs after psychological stress, physical trauma, infection, or surgery.
And though this condition cannot be cured, treatments can reportedly help to provide relief from the symptoms.
7. Gout
This condition which causes sudden severe joint pain due to inflammation mainly affects men aged between 40 and 60.
Since it is similar to other conditions, gout can be difficult to diagnose. However, it causes painful joint pain attacks of the foot, ankle, hand, knee, and wrist. Sufferers of this disease also experience a burning sensation in the foot.
The pain often starts in the feet or toes, and a joint in the big toe. Anti-inflammatory medicines like ibuprofen are usually used to treat attacks of gout.
8. Heart attack
Medically known as myocardial infarction or MI, a heart attack is a serious medical emergency.
This occurs when there is a sudden blockage of blood supply to the heart that is usually caused by a blood clot.
This can be a life-threatening situation as the heart muscle can be seriously damaged due to a lack of blood supply.
Symptoms of a heart attack can include chest pain, feeling anxious, shortness of breath, or weakness. In some cases, chest pain may often be mistaken for indigestion.
9. Complex regional pain syndrome (CRPS)
This is a poorly understood condition whereby a sufferer experiences constantly severe and debilitating pain.
Usually, injury triggers most cases of CRPS, however, the resultant pain is more severe and ongoing than normal. And while the pain tends to affect only one limb, at times it can also affect other parts of the body. Oftentimes, the skin of the affected area can become very sensitive to even the slightest touch, causing severe pain.
The affected areas can also become stiff, swollen, or fluctuate in temperature or colour.
This condition may improve over time, but sufferers may experience pain for many years.
10. Cluster headaches
This rare form of headache begins without warning and are excruciating attack of pain in one side of the head.
Cluster headaches are also often felt around the eye.
Though they are supposedly more common in men, anyone can get them. Also, they can reportedly begin when a person is in their 30s or 40s.
According to cluster headache charity OUCH UK (Organisation for the Understanding of Cluster Headache) "hardly anyone" has heard of the condition – and most people afflicted with it struggle alone with the pain.
The pain due to cluster headaches can last for hours at a time and can be severe enough to continually disrupt daily life.
11. Frozen shoulder
Your shoulder can become frozen when the tissue around the shoulder joint becomes inflamed. A person may experience a stiff and painful shoulder for months and even years.
The NHS informs that the shoulder joint can become so tight and stiff that it may become impossible to carry out simple movements, such as raising your arm.
And though the cause for this condition is not clear, it reportedly could occur due to an injury or diabetes. Doctors usually treat a frozen shoulder with shoulder exercises and painkillers.
12 Broken bones
People can break their bones or experience a fracture either due to an accident like falling or if hit by an object.
Swelling, pain and deformity are the three most common signs of broken bones. But if a bone is not displaced, it may be difficult to tell whether it is broken.
13. Shingles
Also known as herpes zoster, this infection is caused by the same virus as chicken pox.
It is a painful infection of a nerve and the skin surrounding it. This condition usually affects only a particular area on one side of the body and can take many weeks for the rash to heal.
14. Slipped disc
Sudden and lower back pain is often caused due to a slipped disc.
This condition reportedly occurs when the soft cushion of tissue between the vertebrae in the spine pushes out – this tissue presses on the nerves on the spinal cord resulting in excruciating pain and numbness in either an arm or leg.
15. Sickle cell disease
This is a group of inherited health conditions that affect the red blood cells in the body. Sickle cell anaemia is the most serious type.
It is a lifelong condition but treatment can help to manage many of the symptoms of this disease.
16. Migraine
This is a common health condition affecting around 1 in 5 women and 1 in 15 men. A migraine is usually a moderate or severe headache and sufferers experience throbbing pain on one side of the head.
Other symptoms include feeling sick or being sick and increased sensitivity to light or sound.
17. Kidney stones
The passing of kidney stones can cause a sudden, sharp, cramping pain in the side of the abdomen, lower back or occasionally in the groin. If left untreated, kidney stones can lead to kidney infections or malfunction of the kidney.
18. Sciatica
When the sciatic nerve is irritated or compressed in any way, it results in sciatica which is a back problem. This nerve runs right down from the hips to the feet. Moving, sneezing, and coughing may worsen the symptoms of this sciatica.
19. Trigeminal neuralgia
This condition causes sudden, severe facial pain and is usually in one side of the face, which can often be described like an electric shock in the teeth, jaw, or gums.
These painful attacks can last from a few seconds to about two minutes.
20. Pain after surgery
Experiencing pain after surgery is common, however, the intensity varies depending on the type of surgery one undergoes.
The NHS informs that too much pain after surgery is not a good thing and you should never feel you have to "tough it out." It is advised, that if any of your symptoms are worrying you, it is best to visit a GP.
FORMER prime minister Imran Khan, 72, is expected to seek bail in the Al-Qadir Trust case when the Islamabad High Court (IHC) hears petitions on 11 June to suspend the sentences handed to him and his wife Bushra Bibi.
Khan has been held in Adiala Jail since August 2023 in several cases. PTI chief Gohar Ali Khan told ARY News that “June 11 is going to be an important day for both Khan and his wife,” but he gave no further reason. The IHC had earlier adjourned the matter after the National Accountability Bureau (NAB) asked for more time to prepare its arguments.
Gohar said the PTI will work with opposition parties to launch a movement led by the party’s founder from jail. He urged those parties to join “for the sake of the country's survival and security” and added that “The party will address a press conference on June 9 regarding it,” outlining plans for the forthcoming budget.
Last month Khan said he would direct the party’s protest campaign against the Pakistan Muslim League-Nawaz (PML-N)-led coalition from prison. Khyber Pakhtunkhwa Chief Minister Ali Amin Gandapur has warned of a full-scale movement for Khan’s release after Eid Al-Adha.
Khan, convicted in a few cases, continues to claim the 8 February 2023 general election saw the ‘Mother of All Rigging.’ He brands the PML-N and the Pakistan Peoples Party “mandate thieves.”
Special assistant to the prime minister on political affairs Rana Sanaullah on Saturday urged PTI to accept prime minister Shehbaz Sharif’s offer of talks and sit with the government to amend election laws.
Gohar said Bushra Bibi is being held without charges to pressure Khan and insisted no deals would be made for his release. He also dismissed reports of internal rifts within PTI.
The Al-Qadir Trust case centres on a 190 million Pound settlement reached by the United Kingdom’s National Crime Agency (NCA) with the family of property tycoon Malik Riaz. In August 2019 the NCA said it had frozen eight bank accounts containing 100 million pounds “suspected to have derived from bribery and corruption in an overseas nation.”
The agency informed the government then led by Khan’s PTI. It is alleged Khan asked his aide on accountability, Shehzad Akbar, to resolve the matter and that the frozen funds belonging to the national treasury were “settled” against Bahria Town’s liability.
Bahria Town Ltd, Riaz’s real-estate firm, was later found to have illegally acquired large tracts of land on Karachi’s outskirts. It donated hundreds of acres to the Al-Qadir Trust, whose only trustees are Khan and Bushra Bibi.
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Some states continue to report relatively low numbers
India’s total number of active COVID-19 cases has risen above 6,000, with health authorities reporting 358 new infections in the past 24 hours, according to the Ministry of Health and Family Welfare (MoHFW). While there were no Covid related deaths during this period, the increase in cases is prompting state-level monitoring and precautionary measures.
Current case load and recoveries
As of 8:00 a.m. on June 9, 2025, India has 6,491 active Covid-19 cases. The central health ministry confirmed that 358 fresh cases were detected in the last 24 hours, with no fatalities reported in the same timeframe.
According to the ministry’s data, 624 patients recovered or were discharged across the country since the previous update, contributing to the ongoing efforts to manage the spread of the virus through home care and hospital treatment where necessary.
Kerala, Gujarat and Delhi among most affected
Kerala continues to be the worst-affected state, reporting 1,957 active cases. The state added seven new cases in the past day. Gujarat follows with 980 active cases, after recording 158 fresh infections in the same period.
West Bengal stands third with 747 active cases, including 54 new cases reported since Sunday. Delhi is close behind, with 728 active cases, having reported 42 new infections in the last 24 hours. In contrast, Tamil Nadu recorded 25 new cases, bringing its active tally to 219.
Low case numbers in the Northeastern and Eastern states
Some states continue to report relatively low numbers. Assam, for instance, now has six active cases, with two new recoveries in the past 24 hours. Since January 2025, Assam has reported seven total recoveries. Similarly, Odisha reported just four new cases, bringing its total active cases to 34. The state's health department has advised the public, especially those showing flu-like symptoms, to avoid attending the upcoming Rath Yatra in Puri on 27 June.
Situation in Karnataka and other states
Karnataka recorded 57 new Covid-19 cases, increasing its total active case count to 423. Meanwhile, Delhi discharged over 100 patients in the last 24 hours. This trend of simultaneous new infections and recoveries reflects a manageable situation, with healthcare systems largely coping under the current load.
New variants and government advisory
The recent uptick in cases is being attributed to new sub-variants of the Omicron strain, including JN.1, NB.1.8.1, LF.7, and XFC. These variants are believed to be more transmissible but are, so far, associated with milder symptoms. The World Health Organization (WHO) classifies them as "Variants Under Monitoring"—meaning they do not currently pose significant concern but should be watched closely.
The SARS-CoV-2 virus is now regarded as endemic, according to public health experts, and no longer represents the same emergency-level threat it once did. The virus is behaving more like seasonal influenza, with periodic surges expected.
West Bengal urges calm
West Bengal Chief Minister Mamata Banerjee held a review meeting on Monday to assess the state’s Covid-19 preparedness. Emphasising calm, she stated, “There is no need for panic or to get scared about Covid.” She clarified that although the virus still circulates, the government has made adequate preparations at all administrative levels.
Health officials across the country have also encouraged individuals with symptoms to isolate and seek testingiStock
Banerjee added that the WHO now considers Covid endemic, though she advised residents to verify this independently. West Bengal’s tally stood at 747 active cases, including the 54 new infections added on Monday.
Precautionary measures continue
Several states are maintaining or reintroducing basic precautionary measures, especially in public gatherings and institutions. For instance, Odisha plans to reopen schools on 20 June with Covid safety protocols in place, according to Education Minister Nityananda Gond.
Health officials across the country have also encouraged individuals with symptoms to isolate and seek testing, while hospitals and clinics continue to monitor patients for signs of complications.
The impact
While the recent rise in Covid-19 cases in India has drawn attention, authorities emphasise that the situation remains under control. The absence of new deaths, widespread recoveries, and a growing understanding of the current variants are helping states manage the impact more effectively.
Officials continue to urge vigilance, not panic, as the country adapts to living with Covid-19 in its endemic form.
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Yusuf, who resigned as Reform chairman last week before returning two days later, said he wanted to be 'crystal clear' on the party’s stance. (Photo: Getty Images)
ZIA YUSUF has said that Reform UK would deport every illegal immigrant in Britain if the party came to power.
Speaking to BBC Radio 4’s Today programme, Yusuf stated, “We will deport everybody who is here in this country illegally, which is roughly about 1.2 million people.”
Yusuf, who resigned as Reform chairman last week before returning two days later, said he wanted to be “crystal clear” on the party’s stance.
Addressing recent criticisms within the party, he added, “I am Muslim. I don’t therefore think that Islam is a ‘threat to the country’,” but said “resentment” was building due to “two-tier policing.”
He said Islamist terrorism remained a major concern for intelligence agencies and pointed to issues of assimilation. Yusuf described his resignation as a result of “exhaustion” and regretted a tweet criticising new MP Sarah Pochin’s comments on a burqa ban.
Nigel Farage is expected to present Yusuf as a potential cabinet minister while also pledging to reopen some coal mines in south Wales.
Richard Tice, Reform deputy, said Yusuf had faced “horrendous online abuse” and added the party was reorganising to manage growth. Nick Candy will take over Yusuf’s former responsibilities.
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The teenager was walking along Staniforth Road in the Darnall area on Wednesday when a grey Audi reportedly hit an electric bike rider before striking Abdullah. (Photo credit: South Yorkshire Police)
TWO men have been charged with murder and three counts of attempted murder after the death of a 16-year-old boy in an alleged hit-and-run in Sheffield.
Zulkernain Ahmed, 20, and Amaan Ahmed, 26, both from Locke Drive, have been charged over the death of Abdullah Yaser Abdullah Al Yazidi, according to South Yorkshire Police.
The teenager was walking along Staniforth Road in the Darnall area on Wednesday when a grey Audi reportedly hit an electric bike rider before striking Abdullah. He later died in hospital.
An 18-year-old man on the bike was seriously injured but is not believed to be in a life-threatening condition.
The two men are due to appear at Sheffield Magistrates’ Court on Monday. A 46-year-old man and a 45-year-old woman arrested on suspicion of assisting an offender remain on bail.
Abdullah had recently arrived in the UK from Yemen and was preparing to start college. Family and friends said he was devoted to his family and had been learning English.
Darnall councillor Qais Al-Ahdal said, “We’ve really lost someone who is good in the community… May God have mercy on his soul.”
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Israel had vowed in advance to prevent the ship from reaching Gaza
Swedish climate activist Greta Thunberg was among a group of pro-Palestinian campaigners on board a Gaza-bound aid vessel intercepted by Israeli forces and diverted to its shores, the country’s Foreign Ministry confirmed on 9 June.
The ship, Madleen, was organised by the Freedom Flotilla Coalition, a group challenging Israel’s blockade of Gaza. It had departed Sicily on 1 June, carrying a dozen activists and a symbolic amount of humanitarian supplies.
Israeli military blocks flotilla’s progress
Israel had vowed in advance to prevent the ship from reaching Gaza. Defence Minister Yoav Gallant said the military was instructed to stop the vessel “by any means necessary”. The Foreign Ministry later confirmed the Madleen had been redirected to Israel and that its passengers would be repatriated.
In a social media post, the ministry dismissed the effort as a publicity stunt by “celebrities”, referring to it as the “‘selfie yacht’ of the ‘celebrities’”. It accused Thunberg and others of staging a “media provocation”. Footage released showed passengers in life jackets being offered sandwiches and water after interception.
The Freedom Flotilla Coalition claimed it lost contact with the ship after alarms were triggered and drones were seen overhead. The group accused the Israeli military of “kidnapping” the activists. Surveillance footage appeared to show a vessel approaching and personnel boarding the Madleen.
Thunberg voices opposition to blockade
Greta Thunberg, known globally for her environmental activism, has been a strong critic of Israel’s actions in Gaza. Speaking last week, she said, “No matter what odds we are against, we have to keep trying... it’s not even near as dangerous as the silence of the entire world in the face of the live-streamed genocide.”
Israeli Defence Minister Gallant responded sharply, calling Thunberg “an antisemite” and warning that the ship would not be allowed to reach its destination. “Israel will act against any attempt to breach the blockade or aid terrorist organisations,” he said.
Small-scale aid onboard
The Madleen carried a limited quantity of humanitarian goods, including baby formula, flour, rice, medical supplies, children’s prosthetics, and diapers. The Israeli Foreign Ministry called the shipment “tiny”, adding it was “less than a single truckload of aid”.
Israel, along with Egypt, has maintained a blockade on Gaza since Hamas took control of the region in 2007. While Israeli officials say the measure is needed to prevent arms smuggling, rights groups argue it restricts essential goods and worsens the humanitarian crisis.
Repeat of earlier flotilla efforts
This is not the first attempt by activists to challenge the blockade. In 2010, a similar flotilla mission involving the Mavi Marmara ended in bloodshed when Israeli commandos boarded the ship, resulting in the deaths of nine people. A tenth person later died from injuries sustained during the raid.
Israel said its forces were attacked with clubs and knives during the operation. The Freedom Flotilla Coalition described it as “an unlawful and deadly attack”, saying the Madleen’s mission was “a continuation of that legacy”.
A separate mission earlier this year was also thwarted when a ship named Conscience, departing from Tunisia and en route to Malta, caught fire following explosions near the vessel. No injuries were reported, but the mission was called off.
Aid distribution remains contentious
In parallel with the flotilla controversy, Israel has promoted a new aid delivery mechanism via the Gaza Humanitarian Foundation. The group claims to have delivered over 1.1 million meals and 11 truckloads of food on 9 June across three distribution sites.
However, the initiative has faced criticism and has been boycotted by the UN and other major organisations. They accuse Israel of using humanitarian aid as a tool of control and allege that the new system sidelines independent oversight.
The foundation suspended operations temporarily on 8 June, citing threats from Hamas. A spokesperson claimed that local workers received warnings of “serious consequences” if they continued with the aid delivery programme.